منابع مشابه
Clinical recommendations for oxcarbazepine
Oxcarbazepine (OXC) is indicated for treating partial-onset with or without secondary generalized tonic-clonic seizures, in both adults and children aged over 6 years, as monotherapy or adjuvant therapy. Trials data and extensive clinical experience demonstrate generally good tolerability and antiepileptic efficacy similar to carbamazepine (CBZ), sodium valproate or phenytoin. Since the UK laun...
متن کاملOxcarbazepine: a review
Oxcarbazepine recently gained a licence in the UK and USA. The purpose of this article is to review the pharmacology and therapeutics of oxcarbazepine for those prescribers unfamiliar with this interesting new antiepileptic drug1–3. Although only newly licensed in the UK and USA, oxcarbazepine has in fact been in routine clinical use in Denmark and other countries for up to 10 years, and experi...
متن کاملCrystal polymorphism in a carbamazepine derivative: oxcarbazepine.
Although crystal polymorphism of carbamazepine (CBZ), an anticonvulsant used to treat epilepsy, has been known for decades, the phenomenon has only recently been noted for its keto-derivative oxcarbazepine (OCB). Here it is demonstrated that OCB possesses at least three anhydrous polymorphs. Although all forms are morphologically similar, making differentiation between crystal modifications by ...
متن کاملCutaneous adverse drug reactions induced by Oxcarbazepine
Poster background Oxcarbazepine (OXC) is a structural analog of carbamazepine (CBZ). OXC is considered a promising alternative medication for patients who cannot tolerate CBZ because of its equivalent clinical effiecacy and fewer cutaneous adverse drug reactions (cADRs) compared to CBZ. HLAB*15:02 allele was shown to strongly associate with carbamazepine (CBZ)-induced Stevens-Johnson syndrome (...
متن کاملOxcarbazepine Therapy for Complete Central Diabetes Insipidus
Oxcarbazepine and carbamazepine cause hyponatremia by unknown mechanisms. We describe a patient with complete central diabetes insipidus and seizures who developed worsening hyponatremia when her dose of oxcarbazepine was increased. The patient maintained a normal serum sodium level and has had appropriately concentrated urine for 5 years on just oxcarbazepine, despite undetectable antidiuretic...
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ژورنال
عنوان ژورنال: Epilepsia
سال: 1999
ISSN: 0013-9580,1528-1167
DOI: 10.1111/j.1528-1157.1999.tb00918.x